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A ‘Game Changer’ For Organ Transplants: Blood Type of Donor Kidneys Altered in Breakthrough Research_我的网站

A |     Breakthrough new research could significantly increase supply of organs for people with rarer blood types waiting for a transplant, reported The Guardian.,A team of scientists from the University of Cambridge have successfully altered the blood type of three donor kidneys. By flushing blood infused with a special enzyme through a human kidney the scientists removed the blood type markers lining the blood vessels of the organ.,The procedure required using a device that is connected with a donor’s kidney to pass oxygenated blood through it - a normothermic perfusion machine. As a result, the organ was converted to type O, considered the universal donor.,Blood Group Compatible,As the blood type of a donor must be compatible with the recipient’s, the new development could increase the supply of kidneys available for transplant.,A kidney from someone with blood type A cannot be transplanted to someone with blood type B, or visa versa. In such a case, the receiving body’s immune system would reject the new organ, interpreting the different blood type as foreign.,So changing the blood type to the universal O would mean the donor organ could be used for people with any blood type.,“Our confidence was really boosted after we applied the enzyme to a piece of human kidney tissue and saw very quickly that the antigens were removed. After this, we knew that the process is feasible, and we just had to scale up the project to apply the enzyme to full-size human kidneys,” Serena MacMillan, a PhD student at the University of Cambridge, said.,Scientists involved in the research, funded by charity Kidney Research UK and due to be published in the British Journal of Surgery, clarified that the outcome might have particular implications for minority ethnic groups.,Science & TechGood News for ABs: Scientists Can Now Change People's Blood Type21 February, 16:34 GMT,Some blood groups such as O Rh positive and B Rh positive are more prevalent among black, Asian and minority ethnic communities. To complicate matters further, some rare blood types are only found within the black, Asian and minority ethnic communities,This typically places them at a disadvantage, as they struggle to find a match. With low donation rates from these populations, stressed the researchers, sometimes such patients wait for as long as over a year for a compatible donor. They cited figures from 2020-21 showing that just over 9% of total organ donations in the UK came from black and minority ethnic donors. On the other hand, black and minority ethnic patients make up 33% of the kidney transplant waiting list.,“It’s very exciting to think about how this could potentially impact so many lives,” added Serena MacMillan.,The “potentially gamechanging” research was applauded by Dr Aisling McMahon, the executive director of research at Kidney Research UK.,The scientists will now test the reintroduction of other blood types and observe how the novel approach in clinical settings.。    北京时间8月20日，骑士通过多方交易先签后换得到沃特森，接下来的任务就是续约哈登。如今根据ESPN薪资专家Bobby Marks报道，骑士将用延伸条款裁掉惠特摩尔，从而腾出3200万美元签约哈登与另一名球员，而哈登的预计年薪在3200万-3300万美元。

B |          由于沃特森先签后换4年8800万美元合同，直接导致骑士触发第一土豪线（硬帽≈2.09亿美元），球队总薪资被锁死，不能超过该数值，必须做薪资优化才能签约哈登。         根据此前名记Shams报道，骑士通过送出曼恩与快船2027年次轮签，外加部分现金，从奇才交易得到惠特摩尔。

C | 只是骑士并不打算留下惠特摩尔，而是利用惠特摩尔较低薪资，去创造第一工资帽下的灵活性。         根据Bobby Marks报道，骑士将使用延伸条款裁掉惠特莫尔，从而将他下赛季546万美元的薪水，转为三年内每年支付大约180万美元薪水，进而能够腾出约3200万美元空间，去签约哈登与另一名球员。         骑士如今的薪金总额是1.77亿美元。他们已经受到第一土豪线硬工资帽的限制。

D | 在沃特森加盟后，骑士还将续约哈登，届时球队首发五人组会是哈登、米切尔、沃特森、莫布利和阿伦。         哈登的预计薪资大概会落在3200万-3300万美元左右，此前哈登已经跳出原 4232万美元球员选项，骑士没有鸟权，只能用薪资空间直接签约哈登。         哈登的合同年限分歧依然存在，双方还在博弈年薪与保障细节，具体何时官宣签约还是未知数，但无疑距离签约越来越近。

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